Article

Resurrection of a viral internal ribosome entry site from a 700 year old ancient Northwest Territories cripavirus

2021-01-29

Abstract excerpt

<h4>ABSTRACT</h4> The dicistrovirus intergenic region internal ribosome entry site (IGR IRES) uses an unprecedented streamlined mechanism whereby the IRES adopts a triple-pseudoknot (PK) structure to directly bind to the conserved core of the ribosome and drive translation from a non-AUG codon. The origin of this IRES mechanism is not known. Previously, a partial fragment of a divergent dicistrovirus RNA genome,...

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Literature Corpus work: 215d0a96-ea19-546c-afdd-915968bf4f0b
DOI: 10.1101/2021.01.28.428736

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