Article
Diverse genomic and transcriptomic heterogeneity in EGFR-mutant lung adenocarcinoma between exon 19 del and exon 21 L858R.
Cell communication and signaling : CCS - 14 Mar 2026
Yang Yuwen, Qiao Sitan, Sun Dongchen, Zhang Zhonghan, Zhao Yuanyuan, Zhan Jianhua, Huang Yan, Zhao Hongyun, Yang Yunpeng, Wu Kui, Zhou Xinlan, Zhang Lanjun, Long Hao, Yang Haoxian, Wang Junye, Wang Xin, Wen Zhesheng, Zhang Lin, Zhang Li, Fang Wenfeng, Zhao Xin, Zhang Yaxiong
Abstract excerpt
BACKGROUND: The exon 19 deletion (19 Del) and the exon 21 L858R point mutation (21 L858R) are two main subtypes of EGFR-mutant lung adenocarcinoma (LUAD) with distinct response to targeted treatment and immunotherapy. Understanding the intratumor heterogeneity (ITH) of EGFR-mutant LUAD may explain the reason. METHODS: 157 multi-region tumor samples and matched distant normal lung tissues from 29 treatment-naïve...
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