Article
Immune profiles according to EGFR mutant subtypes and correlation with PD-1/PD-L1 inhibitor therapies in lung adenocarcinoma.
Frontiers in immunology - 1 Jan 2023
Koh Young Wha, Park Bumhee, Jung Se Hee, Han Jae-Ho, Haam Seokjin, Lee Hyun Woo
Abstract excerpt
Background: We examined the distributions of 22 immune cell types and the responses to PD-1/PD-L1 inhibitors according to EGFR mutation profile, in three independent datasets of lung adenocarcinoma (LUAD). Methods: We used CIBERSORTx to analyze the distributions of immune cells, and tumor immune dysfunction and exclusion (TIDE) or tumor mutation burden (TMB) to analyze responses to anti-PD-1/PD-L1 therapy, in two...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.