Article

Model-dependent GD2 upregulation in Ewing sarcoma with the EZH2 inhibitor tazemetostat: Prerequisites for combination with GD2-specific CAR T cells

2026-07-24

Abstract excerpt

<title>Abstract</title> <p>The disialoganglioside GD2 is a cell surface marker of neuroblastoma and an attractive target for chimeric antigen receptor (CAR) T-cell therapy. GD2 is also expressed in Ewing sarcoma (EwS), but more heterogeneously and often below the threshold required for CAR-mediated T-cell activation. We previously showed that pharmacological inhibition of the epigenetic regulator Enhancer of Zest...

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Literature Corpus work: 220ec975-2762-51bf-a28a-e11e47557881
DOI: 10.21203/rs.3.rs-10369352/v1

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Model-dependent GD2 upregulation in Ewing sarcoma with the EZH2 inhibitor tazemetostat: Prerequisites for combination with GD2-specific CAR T cellsDOI 10.21203/rs.3.rs-10369352/v1Read

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