Article

Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound

2018-11-07

Abstract excerpt

We have previously reported the inhibition of bacterial topoisomerase I activity by a fluoroquinophenoxazine compound (FP-11g) with a 6-bipiperidinyl lipophilic side chain that exhibited promising antituberculosis activity (MIC = 2.5 μM against Mycobacterium tuberculosis , SI = 9.8). Here, we found that the compound is bactericidal towards Mycobacterium smegmatis , resulting in greater than 5 Log 10 reduction i...

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Literature Corpus work: 21440d12-c96a-59ac-8352-0605a15f62ab
DOI: 10.1101/464990

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