Article
Piezo1 is required for outflow tract and aortic valve development.
Journal of molecular and cellular cardiology - 1 Jun 2020
Faucherre Adèle, Moha Ou Maati Hamid, Nasr Nathalie, Pinard Amélie, Theron Alexis, Odelin Gaëlle, Desvignes Jean-Pierre, Salgado David, Collod-Béroud Gwenaëlle, Avierinos Jean-François, Lebon Guillaume, Zaffran Stéphane, Jopling Chris
Abstract excerpt
AIMS: During embryogenesis, the onset of circulatory blood flow generates a variety of hemodynamic forces which reciprocally induce changes in cardiovascular development and performance. It has been known for some time that these forces can be detected by as yet unknown mechanosensory systems which in turn promote cardiogenic events such as outflow tract and aortic valve development. PIEZO1 is a mechanosensitive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.