Article

Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit

2025-04-04

Abstract excerpt

Our overarching aim was to determine how hypoxia affects the extracellular matrix (ECM). Transcriptomic analysis (21,941 patients; 10 cancer types) identified ECM remodelling as the predominant pathway affected by hypoxia. Multi-omics confirmed that hypoxia impacts ECM organisation and collagen degradation; 53 ECM genes were affected, of which 74% were HIF1/HIF2-regulated. Spatial transcriptomics highlighted diffe...

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Literature Corpus work: 211b208b-58eb-593f-9e08-48ae637cb88a
DOI: 10.1101/2025.04.04.647191

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