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Article

SIRT1 regulation of apoptosis of human chondrocytes

27 Aug 2009

Abstract excerpt

OBJECTIVE: SIRT1 is known to inhibit apoptosis and to promote survival of various types of cells. However, the roles of SIRT1 in apoptosis of human chondrocytes have never been reported. We undertook this study to investigate the relationship of SIRT1 to apoptosis of human chondrocytes, which is a characteristic feature of osteoarthritis (OA). METHODS: The expression of SIRT1 in human chondrocytes was examined by...

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PMID: 19714620
DOI: 10.1002/art.24864

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