Article

DRP1-mediated regulation of mitochondrial dynamics determines the apoptotic response upon embryonic differentiation

2019-11-08

Abstract excerpt

The changes that drive differentiation create a large potential for the emergence of abnormal cells that need to be removed before they contribute to further development or the germline. This removal is in part achieved by cells becoming hypersensitive to death upon exit of naïve pluripotency. What causes this change in apoptotic response is unknown. Here we identify that it is controlled by the regulator of mitoc...

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Literature Corpus work: 20c45835-0813-5df8-9ee2-c545927a2039
DOI: 10.1101/835751

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