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ER Stress-Induced β-Cell Apoptosis is Linked to Novel Select Lipid Signaling at the Transcriptional Level: Implications in T1D Developmen <i>t</i>

2026-03-04

Abstract excerpt

Type 1 diabetes (T1D) is a consequence of β-cell death. ER stress precedes T1D onset and prolonged ER stress in β-cells can lead to β-cell apoptosis. We reported that lipid signaling generated by the Ca 2+ -independent phospholipase A 2 β (iPLA 2 β), encoded by Pla2g6 , participates in ER stress-mediated β-cell apoptosis. β-Cell membranes are enriched in arachidonic acid containing glycerophospholipids and the...

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Literature Corpus work
20b2ca13-0620-5d22-b6fe-c198c0298349
DOI
10.64898/2026.03.02.708596
Open publication

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ER Stress-Induced β-Cell Apoptosis is Linked to Novel Select Lipid Signaling at the Transcriptional Level: Implications in T1D Developmen <i>t</i>DOI 10.64898/2026.03.02.708596
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