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Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy

5 Sept 2022

Abstract excerpt

microRNAs (miRNAs) are a class of non-coding functional small RNA composed of 21-23 nucleotides, having multiple associations with liver fibrosis. Fibrosis-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis types. The former is capable of activating hepatic stellate cells (HSCs) by modulating pro-fibrotic signaling pathways, mainly including TGF-β/SMAD, WNT/β-catenin, and Hedgehog; the...

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PMID: 37397560
DOI: 10.1016/j.gendis.2022.08.013

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