Article

Simvastatin therapy in different subtypes of hypercholesterolemia – a physiologically based modelling approach

2023-02-02

Abstract excerpt

<h4>ABSTRACT</h4> Hypercholesterolemia is a multifaceted plasma lipid disorder with heterogeneous causes including lifestyle and genetic factors. A key feature of hypercholesterolemia is elevated plasma levels of low-density lipoprotein cholesterol (LDL-C). Several genetic variants have been reported to be associated with hypercholesterolemia, known as familial hypercholesterolemia (FH). Important variants affect...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7f7ed1b8-b25f-519d-8840-dade4a6963a6
DOI: 10.1101/2023.02.01.23285358

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Simvastatin therapy in different subtypes of hypercholesterolemia – a physiologically based modelling approachDOI 10.1101/2023.02.01.23285358Read

Familial Hypercholesterolemia: The Most Frequent Cholesterol Metabolism Disorder Caused DiseaseSemantic proximity Read

Molecular aspects of hypercholesterolemia treatment: current perspectives and hopes.Semantic proximity Read

Explaining clinically important variability in response to simvastatin treatment using a PBPK/PD approach.Semantic proximity Read

Familial hypercholesterolemia.Semantic proximity Read

The pharmacogenomics of statins.Semantic proximity Read

[PERSONALIZED APPROACH TO LIPID-LOWERING THERAPY].Semantic proximity Read

ANGPTL3 binds to PCSK9 to coordinately regulate intracellular lipid homeostasisSemantic proximity Read

Familial Hypercholesterolemia: Although Identification Advances, Appreciation and Treatment Lag.Semantic proximity Read

Impact of Pharmacogenetics on Efficacy and Safety of Statin Therapy for DyslipidemiaSemantic proximity Read

When the same treatment has different response: The role of pharmacogenomics in statin therapySemantic proximity Read

Molecular pathology of familial hypercholesterolemia, related dyslipidemias and therapies beyond the statins.Semantic proximity Read

Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis.Semantic proximity Read