Article

High-coverage immunopeptidomics using timsTOF mass spectrometers with Thunder-DDA-PASEF boosted by MS2Rescore

2024-08-06

Abstract excerpt

<title>Abstract</title> <p> Major histocompatibility complex (MHC, or Human leukocyte antigen, HLA) peptide ligands can be exploited to develop immunotherapies targeting immunogenic disease-specific immunopeptides, such as virus- or cancer mutation-derived peptides. Liquid chromatography-coupled with mass spectrometry (LC-MS)-based immunopeptidomics is the gold standard for identifying MHC ligands. We previously...

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Literature Corpus work: bc633b99-3e45-5657-8f22-a0b026502c90
DOI: 10.21203/rs.3.rs-4849156/v1

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