Article

ODELAM: Rapid sequence-independent detection of drug resistance in clinical isolates of Mycobacterium tuberculosis

2020-03-19

Abstract excerpt

Antimicrobial-resistant Mycobacterium tuberculosis (Mtb) causes over 200,000 deaths each year. Current assays of antimicrobial resistance need knowledge of mutations that confer drug resistance, or long periods of culture time to test growth under drug pressure. We present ODELAM (One-cell Doubling Evaluation of Living Arrays of Mycobacterium), a time-lapse microscopy-based method that observes individual cells gr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ebf69c41-0cd7-5971-a270-0c8a7100c985
DOI: 10.1101/2020.03.17.995480

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ODELAM: Rapid sequence-independent detection of drug resistance in clinical isolates of Mycobacterium tuberculosisDOI 10.1101/2020.03.17.995480Read

Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium tuberculosis Clinical IsolatesSemantic proximity Read

Antibiotic lethality dictates mycobacterial infection outcomesSemantic proximity Read

Luciferase reporter mycobacteriophage (TM4:: GeNL ) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complexSemantic proximity Read

Dictyosteliumdiscoideum–Mycobacterium marinum infection model: a powerful high-throughput screening platform for anti-infective compoundsSemantic proximity Read

Tiled Amplicon Sequencing Enables Culture-free Whole-Genome Sequencing of Pathogenic Bacteria From Clinical SpecimensSemantic proximity Read

Droplet-based digital antibiotic susceptibility screen reveals single-cell clonal heteroresistance in an isogenic bacterial population.Semantic proximity Read

Transcriptome signature of cell viability predicts drug response and drug interaction for TuberculosisSemantic proximity Read

Tre-DST: A new drug susceptibility test for <i>Mycobacterium tuberculosis</i> using solvatochromic trehalose probesSemantic proximity Read

Molecular Analysis of Linezolid-Resistant Clinical Isolates of Mycobacterium abscessusSemantic proximity Read

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy.Semantic proximity Read

Assessing the Impact of Bedaquiline, Clofazimine, and Linezolid on Mycobacterial Genome Integrity.Semantic proximity Read

Automated detection of bacterial growth on 96-well plates for high-throughput drug susceptibility testing of Mycobacterium tuberculosisSemantic proximity Read