Article

“Hyper-Hypermethylated Status” of the MGMT Gene Promoter Confers Additional Survival Benefits in IDH-Wild-Type Glioblastoma Patients

2021-02-09

Abstract excerpt

<title>Abstract</title> IntroductionMethylation status of the O(6)-Methylguanine-DNA methyltransferase (<italic>MGMT</italic>) promoter plays key role in glioblastoma (GBM) with respect to the patient’s responses to temozolomide chemotherapy and disease prognosis. Although the cut-off value of <italic>MGMT</italic> methylation (≥10%) is currently widely used to dichotomize the<italic> MGMT </italic>status as “...

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Literature Corpus work: 1fc08531-bdcb-567e-b02b-01392e663ecd
DOI: 10.21203/rs.3.rs-178009/v1

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