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Association of MGMT Gene Promoter Methylation With Clinicopathological Parameters in Patients With Wild-type IDH Glioblastoma.

Anticancer research - 1 Jan 2022

Kim Moonsik, Yoo Jihwan, Chang Jong Hee, Kim Se Hoon

Abstract excerpt

BACKGROUND: The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter plays a key role in response to temozolomide chemotherapy and disease prognosis in patients with wild-type isocitrate dehydrogenase (IDH) glioblastoma (GBM). PATIENTS AND METHODS: The MGMT promoter methylation status and its association with clinicopathological parameters were retrospectively analysed in a cohort of...

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DNA Modification Methylases
DNA Repair Enzymes
Glioblastoma
Isocitrate Dehydrogenase
Progression-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Proteins

X-linked Nuclear Protein

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PMID: 34969742
DOI: 10.21873/anticanres.15490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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