Article

The IL-12Rβ2 gene functions as a tumor suppressor in human B cell malignancies

2004-06-01

Abstract excerpt

The IL-12Rbeta2 gene is expressed in human mature B cell subsets but not in transformed B cell lines. Silencing of this gene may be advantageous to neoplastic B cells. Our objective was to investigate the mechanism(s) and the functional consequence(s) of IL-12Rbeta2 gene silencing in primary B cell tumors and transformed B cell lines. Purified tumor cells from 41 patients with different chronic B cell lymphoprolif...

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Literature Corpus work: 1f3146bd-5cf8-5b80-a71b-d32f70285618
DOI: 10.1172/jci200420303

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