Article

Identification of Novel Chemical Entities for Mirk/Dyrk1B Receptor Using Molecular Modeling and Molecular Dynamic Approaches

2021-12-16

Abstract excerpt

Cancer is a major health problem worldwide and one of the leading death-causing diseases. Mirk (Minibrain-related kinase is a member of the dual-specificity tyrosine-phosphorylation-regulated kinase (Dyrk) family that is highly upregulated in various solid tumors and mediates cell survival including lung cancer. Mirk effectively increases the expression of a series of antioxidant genes, which scavenge the reactive...

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Literature Corpus work: 1ef7f1e1-482a-5cc1-b83a-18b0942cc12b
DOI: 10.21203/rs.3.rs-1141061/v1

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