Article
Natural inhibitors of DYRK1A as drug candidates against Alzheimer Disease: QSAR, molecular docking, molecular dynamics simulation and drug evaluation assessment
2023-01-09
Abstract excerpt
Alzheimer’s disease (AD) is a dementia neurodegenerative disorder with complex mechanisms and no cure that gradually leads to loss of learning, remembering, imagining, and recalling past events. It is most commonly found in adults aged 65 and up. The research scientists are interested in producing new drugs and new drug targets that can cure or inhibit this incurable disease. The In-silico technique was used to in...
Topics
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- Advanced Glycation End Products research
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Down syndrome and intellectual disability research
- Hydrogen Bonding
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Molecular Dynamics Simulation
Identifiers and source
- Literature Corpus work
- 70d194a1-b9e9-5a1e-addc-bd82e2d8786b
- DOI
- 10.21203/rs.3.rs-2443598/v1
