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Article

Clonal Hematopoiesis of Indeterminate Potential From a Heart Failure Specialist's Point of View.

Journal of the American Heart Association - 1 Aug 2023

Sikking Maurits A, Stroeks Sophie L V M, Waring Olivia J, Henkens Michiel T H M, Riksen Niels P, Hoischen Alexander, Heymans Stephane R B, Verdonschot Job A J

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is a common bone marrow abnormality induced by age-related DNA mutations, which give rise to proinflammatory immune cells. These immune cells exacerbate atherosclerotic cardiovascular disease and may induce or accelerate heart failure. The mechanisms involved are complex but point toward a central role for proinflammatory macrophages and an...

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Identifiers

PMID: 37489738
DOI: 10.1161/JAHA.123.030603
PMCID: PMC10492961

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