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Article

MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers.

Proceedings of the National Academy of Sciences of the United States of America - 27 Aug 2019

Srinivasan Gayathri, Williamson Elizabeth A, Kong Kimi, Jaiswal Aruna S, Huang Guangcun, Kim Hyun-Suk, Schärer Orlando, Zhao Weixing, Burma Sandeep, Sung Patrick, Hromas Robert

Abstract excerpt

Defects in DNA repair give rise to genomic instability, leading to neoplasia. Cancer cells defective in one DNA repair pathway can become reliant on remaining repair pathways for survival and proliferation. This attribute of cancer cells can be exploited therapeutically, by inhibiting the remaining repair pathway, a process termed synthetic lethality. This process underlies the mechanism of the Poly-ADP ribose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31395736
DOI: 10.1073/pnas.1903150116
PMCID: PMC6717293

Genes

BRCA1
BAP1
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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