An integrative analysis of clinical and epigenetic biomarkers of mortality

Abstract excerpt

DNA methylation (DNAm) has been reported to be associated with many diseases and mortality. We hypothesized that the integration of DNAm with clinical risk factors would improve mortality prediction.We performed an epigenome-wide association study of whole blood DNAm in relation to mortality in 15 cohorts (n=15,013). During a mean follow-up of 10 years, there were 4314 deaths from all-causes including 1235 cardiov...

Topics

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• Access to Information
• Birth, Development, and Health
• Cause of Death
• Data Mining
• Databases, Factual
• Genetic Associations and Epidemiology
• Health Status
• Liver Disease Diagnosis and Treatment

Identifiers and source

Literature Corpus work

1e996d65-bb9a-58df-9dd5-46bdec897ac9

DOI

10.1101/2022.01.24.22269611