Article
Identification of DNA methylation signatures of smoking in women and associations with cardiovascular disease mortality.
Communications biology - 9 Jun 2026
Khodasevich Dennis, Shadyab Aladdin H, Maihofer Adam X, Nievergelt Caroline M, Wallace Robert, Martin Lisa W, Bozack Anne K, de la Rosa Rosemarie, Stefanick Marcia L, Franceschini Nora, Cardenas Andres
Abstract excerpt
Tobacco smoking is critical risk factor for cardiovascular disease (CVD) and mortality, with epigenetics implicated as a key biological mechanism. Smoking disproportionately impacts CVD risk in women; however, limited research has examined smoking-associated DNA methylation (DNAm) changes in women. We measure whole blood DNAm (EPICv2) and self-reported smoking (three-category, pack-years, and years since...
Read the complete abstract on PubMedTopics
- Humans
- Female
- DNA Methylation
- Cardiovascular Diseases
- Smoking
- Epigenesis, Genetic