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Article

Blood-derived DNA methylation predictors of mortality discriminate tumor and healthy tissue in multiple organs.

Molecular oncology - 1 Sept 2020

Zhang Yan, Bewerunge-Hudler Melanie, Schick Matthias, Burwinkel Barbara, Herpel Esther, Hoffmeister Michael, Brenner Hermann

Abstract excerpt

Evidence has shown that certain methylation markers derived from blood can mirror corresponding methylation signatures in internal tissues. In the current study, we aimed to investigate two strong epigenetic predictors for life span, derived from blood DNA methylation data, in tissue samples of solid cancer patients. Using data from the Cancer Genome Atlas (TCGA) and the German DACHS study, we compared a...

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PMID: 32506842
DOI: 10.1002/1878-0261.12738
PMCID: PMC7463320

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