Article

Human embryos arrest in a quiescent-like state characterized by metabolic and zygotic genome activation problems

2021-12-21

Abstract excerpt

Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction between the 3-8-cell stage, posing a significant clinical problem. The mechanisms behind this arrest are unclear. Here, we show that the arrested embryos enter a quiescent-like state, marked by cell cycle arrest, the downregulation of ribosomes and histones and downregulation of MYC and p53 activity. Mechanistically, the a...

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Literature Corpus work: 58f2b281-3847-58cd-b973-a455b7e377df
DOI: 10.1101/2021.12.19.473390

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