Article

Transient Hsp90 suppression promotes a heritable change in protein translation

2018-07-10

Abstract excerpt

The heat shock protein 90 (Hsp90) chaperone functions as a protein-folding buffer and plays a unique role promoting the evolution of new heritable traits. To investigate the role of Hsp90 in modulating protein synthesis, we screened more than 1200 proteins involved in mRNA regulation for physical interactions with Hsp90 in human cells. Among the top hits was CPEB2, which strongly binds Hsp90 via its prion domain,...

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Literature Corpus work: 1e8acc1d-5dd0-59c4-8bc3-4be0781bb9c7
DOI: 10.1101/366070

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