Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas

Abstract excerpt

Diffuse gliomas are incurable primary brain tumors encompassing three histo-molecular subtypes: glioblastomas (GB), astrocytomas, and oligodendrogliomas. The latter two harbor IDH1 mutations and exhibit slower progression than glioblastomas. Diffuse gliomas are composed of highly plastic tumor cells capable of transitioning between astrocyte-like, oligodendrocyte-like, progenitor-like, and mesenchymal-like states,...

Topics

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• Glioma
• Immunoenzyme Techniques
• Isocitrate Dehydrogenase
• Neoplasm Grading
• Neovascularization, Pathologic
• Real-Time Polymerase Chain Reaction
• Receptor, Endothelin B
• T-Lymphocytes, Cytotoxic

Identifiers and source

Literature Corpus work

1e73cef9-8525-5b22-a40e-ac45312f7697

DOI

10.1101/2025.09.05.674570