Article
Keratins and the keratinocyte activation cycle.
The Journal of investigative dermatology - 1 May 2001
Freedberg I M, Tomic-Canic M, Komine M, Blumenberg M
Abstract excerpt
In wound healing and many pathologic conditions, keratinocytes become activated: they turn into migratory, hyperproliferative cells that produce and secrete extracellular matrix components and signaling polypeptides. At the same time, their cytoskeleton is also altered by the production of specific keratin proteins. These changes are orchestrated by growth factors, chemokines, and cytokines produced by...
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