Article
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.
Nature medicine - 1 Jan 2017
Workman Michael J, Mahe Maxime M, Trisno Stephen, Poling Holly M, Watson Carey L, Sundaram Nambirajan, Chang Ching-Fang, Schiesser Jacqueline, Aubert Philippe, Stanley Edouard G, Elefanty Andrew G, Miyaoka Yuichiro, Mandegar Mohammad A, Conklin Bruce R, Neunlist Michel, Brugmann Samantha A, Helmrath Michael A, Wells James M
Abstract excerpt
The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse functions, including motility and epithelial permeability. Perturbations in ENS development or function are common, yet there is no human model for studying ENS-intestinal biology and disease. We used a tissue-engineering approach with embryonic and induced pluripotent stem cells (PSCs) to generate human intestinal tissue...
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