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Article

Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen.

Cell host & microbe - 12 Jul 2017

Roach Dwayne R, Leung Chung Yin, Henry Marine, Morello Eric, Singh Devika, Di Santo James P, Weitz Joshua S, Debarbieux Laurent

Abstract excerpt

The rise of multi-drug-resistant (MDR) bacteria has spurred renewed interest in the use of bacteriophages in therapy. However, mechanisms contributing to phage-mediated bacterial clearance in an animal host remain unclear. We investigated the effects of host immunity on the efficacy of phage therapy for acute pneumonia caused by MDR Pseudomonas aeruginosa in a mouse model. Comparing efficacies of phage-curative...

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Source

Identifiers

PMID: 28704651
DOI: 10.1016/j.chom.2017.06.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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