Hypertrophic Cardiomyopathy is a Disease of Sarcomere Proteins.

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a primary disease of cardiac myocytes caused by mutations in genes encoding sarcomere proteins. The ensuing phenotype, however, is multicellular, induced by biological and functional changes in myocytes and non-myocyte cardiac cells, particularly fibroblasts. The molecular genetic basis of HCM has been partially elucidated, and over three dozen genes are implicated as causes...

Topics

• Humans
• Sarcomeres
• Genetic Predisposition to Disease
• Mutation
• Phenotype
• Myosin Binding Protein C
• Carrier Proteins