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Metallothionein Is Inappropriate to Neutralise Excess Hepatic Copper in Wilson’s Disease

2025-12-22

Abstract excerpt

Mutations in ATP7B impair biliary copper excretion and copper–ceruloplasmin release, causing hepatic copper overload in Wilson’s disease (WD). Metallothionein (MT), a key intracellular copper buffering agent, is overexpressed in WD liver. We evaluated the diagnostic significance of MT immunostaining in explanted livers from hepatic and neurological WD, including untreated cases and those receiving short- versus lo...

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Literature Corpus work
96a5536d-7ebb-54b4-817c-18b13199d52f
DOI
10.20944/preprints202512.1851.v1
Open publication

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