Article

Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices

2023-06-11

Abstract excerpt

Circulating monocytes are recruited to the tumor microenvironment, where they can differentiate into macrophages that mediate tumor progression. To reach the tumor microenvironment, monocytes must first extravasate and migrate through the type-1 collagen rich stromal matrix. The viscoelastic stromal matrix around tumors not only stiffens relative to normal stromal matrix, but often exhibits enhanced viscous charac...

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Literature Corpus work: 1d52f9b0-8670-5ec7-be3e-8f38d33c7608
DOI: 10.1101/2023.06.09.544394

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