Article

Sort-purification of human CD34 <sup>+</sup> CD90 <sup>+</sup> cells reduces target cell population and improves lentiviral transduction for gene therapy

2019-11-26

Abstract excerpt

<h4> ABSTRACT </h4> Hematopoietic stem cell (HSC) gene therapy has the potential to cure many genetic, malignant and infectious diseases. We have shown in a nonhuman primate (NHP) HSC gene therapy and transplantation model that the CD34 + CD90 + cell fraction was exclusively responsible for multilineage engraftment and hematopoietic reconstitution. Here we show the translational potential of this HSC-enriched...

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Literature Corpus work: 1d2907f5-6af8-5b0f-b872-dbd189f303ac
DOI: 10.1101/850479

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