Article

A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket

2026-04-05

Abstract excerpt

Frailty, defined by progressive loss of physiological resilience, neuromuscular function, and cognitive capacity, is a central manifestation of biological aging yet remains difficult to quantify in scalable experimental systems. Here, we introduce a Composite Frailty Index (CFI) in the house cricket ( Acheta domesticus ) that integrates automated measures of locomotion, exploratory behavior, and freezing into a u...

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Literature Corpus work: 1cb2b1c2-d98b-5b8a-b101-50611cf299a1
DOI: 10.64898/2026.04.01.715973

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