Article

Hypermethylation of Mest Promoter Causes Aberrant Wnt Signaling in the Patients of Alzheimer’s Disease

2021-05-06

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: The expression of mesoderm-specific transcript (Mest) is regulated by genomic imprinting where only the paternal allele is active for transcription. Mest is a candidate gene for Silver-Russell Syndrome, and hypermethylation of Mest promoter is associated with oligozoospermia. In addition, Loss of imprinting (LOI) is often associated with various neurodegenerativ...

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Literature Corpus work: 1c8297d3-5af2-59f3-9182-9a37a57f44ca
DOI: 10.21203/rs.3.rs-474622/v1

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