Article

Adjusting for principal components of molecular phenotypes induces replicating false positives

2017-03-26

Abstract excerpt

High-throughput measurements of molecular phenotypes provide an unprecedented opportunity to model cellular processes and their impact on disease. Such highly-structured data is strongly confounded, and principal components and their variants reliably estimate latent confounders. Conditioning on PCs in downstream analyses is known to improve power and reduce multiple-testing miscalibration and is an indispensable...

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Literature Corpus work: 1c59e5af-766a-53ae-8ddb-a9e334ba5a23
DOI: 10.1101/120899

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