Article

Th17.1 cell driven sarcoidosis-like inflammation after anti-BCMA CAR T cells in multiple myeloma

2022-12-08

Abstract excerpt

<h4>ABSTRACT</h4> Pseudo-progression and flare-up phenomena constitute a novel diagnostic challenge in the follow-up of patients treated with immune-oncology drugs. We present a case study on pulmonary flare-up after Idecabtagen Vicleucel (Ide-cel), a BCMA targeting CAR T-cell therapy, and used single-cell RNA-seq (scRNA-seq) to identify a Th17.1 driven autoimmune mechanism as the biological underpinning of this p...

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Literature Corpus work: 1c3bd2ca-7719-5b37-addd-2b3ab60f4d74
DOI: 10.1101/2022.12.08.22283148

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