Article

Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders

2021-12-20

Abstract excerpt

De novo mutations contribute to a large proportion of sporadic psychiatric and developmental disorders, yet the potential role of environmental carcinogens as drivers of causal de novo mutations in neurodevelopmental disorders is poorly studied. We demonstrate that several mutagens, including polycyclic aromatic hydrocarbons (PAHs), disproportionately mutate genes related to neurodevelopmental disorders including...

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Identifiers and source

Literature Corpus work: 7dc02613-1386-5444-93da-e58fbb20dcdf
DOI: 10.1101/2021.12.17.473207

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