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Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic cutaneous melanoma

2025-08-15

Abstract excerpt

<h4>Background</h4> The emergence of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of metastatic melanoma. However, despite its success, reliable biomarkers for predicting primary resistance are not available in clinical practice. This study seeks to identify predictors of primary resistance based on novel gene expression signatures using pre-treatment multidimensional profiling in m...

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Literature Corpus work
67592d58-eb7a-53d4-862b-59c1d6d71b4f
DOI
10.1101/2025.08.13.670062
Open publication

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Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic cutaneous melanomaDOI 10.1101/2025.08.13.670062
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