Back to search

Article

L-methionine sulfoximine interacted with propofol and showed toxicity in PC12 cells

2019-06-16

Abstract excerpt

<h4>Background: </h4> L-Methionine sulfoximine (MSO) inhibits glutamine synthesis in a rodent animal model, and its limited clinical use is implicitly associated with glutamate deprivation and neurotoxicity. The purpose of this experiment was to determine the effect of MSO on pheochromocytoma (PC12) cells and its interaction with propofol-induced neuro-apoptosis. <h4>Objective:</h4> To study the effects of MSO on...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1ba8d68b-4b3a-5994-85cd-d24e77051d1f
DOI
10.7287/peerj.preprints.27803v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
L-methionine sulfoximine interacted with propofol and showed toxicity in PC12 cellsDOI 10.7287/peerj.preprints.27803v1
The protective role of mesencephalic astrocyte-derived neurotrophic factor in endoplasmic reticulum stress in RT4-D6P2T schwannoma sells with the S63del MPZ mutation.Semantic proximity
Propofol enhances stem-like properties of glioma via GABAAR‐dependent Src modulation of ZDHHC5-EZH2 palmitoylation mechanismSemantic proximity
Propofol Attenuates Lung but not Brain Cancer Cell Malignancy through Metabolism and Cell Signaling Modulation&nbsp;In VitroSemantic proximity
A new mechanism of POCD caused by sevoflurane in mice: apoptosis induced by cross-dysfunction of iron and glucose metabolismSemantic proximity
The protection of 2-D08 to sevoflurane-induced hypomyelination is mediated by Kir4.1Semantic proximity
Assessment of a new class of slow γ-aminobutyric acid type A receptor anesthetic on mouse neuronal and astrocyte mitochondrial functionSemantic proximity
The effect of esketamine on perioperative neurocognitive dysfunction in elderly patients who underwent gastrointestinal tumor surgery: a randomized double-blind controlled studySemantic proximity
Beclin1-mediated ferroptosis activation is associated with isoflurane-induced toxicity in SH-SY5Y neuroblastoma cellsSemantic proximity
Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation in MicrogliaSemantic proximity
Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome NeurotoxicitySemantic proximity
SSADH Variants Increase Susceptibility of U87 Cells to Mitochondrial Pro-Oxidant Insult.Semantic proximity
Protective effect of 4-Phenylbutyrate against proteolipid protein mutation-induced endoplasmic reticulum stress and oligodendroglial cell death.Semantic proximity
Select a neighboring publication to make it the new centre.