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Article

SSADH Variants Increase Susceptibility of U87 Cells to Mitochondrial Pro-Oxidant Insult.

International journal of molecular sciences - 19 Jun 2020

Menduti Giovanna, Vitaliti Alessandra, Capo Concetta Rosa, Lettieri-Barbato Daniele, Aquilano Katia, Malaspina Patrizia, Rossi Luisa

Abstract excerpt

Succinate semialdehyde dehydrogenase (SSADH) is a mitochondrial enzyme, encoded by ALDH5A1, mainly involved in γ-aminobutyric acid (GABA) catabolism and energy supply of neuronal cells, possibly contributing to antioxidant defense. This study aimed to further investigate the antioxidant role of SSADH, and to verify if common SNPs of ALDH5A1 may affect SSADH activity, stability, and mitochondrial function. In this...

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Identifiers

PMID: 32575506
DOI: 10.3390/ijms21124374
PMCID: PMC7352567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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