Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity.

European urology - 1 May 2013

Beltran Himisha, Yelensky Roman, Frampton Garrett M, Park Kyung, Downing Sean R, MacDonald Theresa Y, Jarosz Mirna, Lipson Doron, Tagawa Scott T, Nanus David M, Stephens Philip J, Mosquera Juan Miguel, Cronin Maureen T, Rubin Mark A

Abstract excerpt

BACKGROUND: Most personalized cancer care strategies involving DNA sequencing are highly reliant on acquiring sufficient fresh or frozen tissue. It has been challenging to comprehensively evaluate the genome of advanced prostate cancer (PCa) because of limited access to metastatic tissue. OBJECTIVE: To demonstrate the feasibility of a novel next-generation sequencing (NGS)-based platform that can be used with...

Topics

Join the communities discussing this publication.

Androgen Antagonists
Antineoplastic Agents, Hormonal
Biopsy, Needle
Fixatives

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Paraffin Embedding

Tissue Fixation

Source

Open in PubMed Open full text

Identifiers

PMID: 22981675
DOI: 10.1016/j.eururo.2012.08.053
PMCID: PMC3615043

Genes

ATM
BRAF
BRCA2
ERG
MYC
PTEN
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity.PMID 22981675Read ↗

Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision MakingSemantic proximity Read ↗

Next-generation sequencing technology in prostate cancer diagnosis, prognosis, and personalized treatment.Semantic proximity Read ↗

Integrative clinical genomics of advanced prostate cancer.Semantic proximity Read ↗

DNA alterations in the tumor genome and their associations with clinical outcome in prostate cancer.Semantic proximity Read ↗

Next-generation sequencing of prostate cancer: genomic and pathway alterations, potential actionability patterns, and relative rate of use of clinical-grade testingSemantic proximity Read ↗

The genomic landscape of prostate cancerSemantic proximity Read ↗

The Genomic and Molecular Pathology of Prostate Cancer: Clinical Implications for Diagnosis, Prognosis, and TherapySemantic proximity Read ↗

A Pilot Study of Clinical Targeted Next Generation Sequencing for Prostate Cancer: Consequences for Treatment and Genetic Counseling.Semantic proximity Read ↗

Comprehensive Analysis of AR Alterations in Circulating Tumor DNA from Patients with Advanced Prostate Cancer.Semantic proximity Read ↗

Molecular pathology of prostate cancer revealed by next-generation sequencing: opportunities for genome-based personalized therapy.Semantic proximity Read ↗

The mutational landscape of prostate cancer.Semantic proximity Read ↗

Precision medicine for advanced prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.