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Article

Real-world prevalence of homologous recombination repair mutations in advanced prostate cancer: an analysis of two clinico-genomic databases.

Prostate cancer and prostatic diseases - 1 Dec 2024

Shui Irene M, Burcu Mehmet, Shao Changxia, Chen Cai, Liao Chi-Yin, Jiang Shan, Cristescu Razvan, Parikh Ravi B

Abstract excerpt

BACKGROUND: Homologous recombination repair mutation (HRRm) status may guide risk-stratification and treatment decisions, including polyadenosine diphosphate-ribose polymerase inhibitor use, in advanced prostate cancer. Although HRRm prevalence has been reported in single-institution studies or clinical trials, real-world HRRm prevalence in diverse populations is unknown. We describe HRRm in the clinical setting...

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Identifiers

PMID: 38057611
DOI: 10.1038/s41391-023-00764-1
PMCID: PMC11543596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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