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Article

Characterizing Longitudinal Molecular Changes in ctDNA in Patients with Metastatic Castration-Resistant Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2026

Jani Chinmay T, Tran Eli, Zhang Nicole, Tsai Jill, Dong Jianjie, Bucheit Leslie, Pan Elizabeth, Panian Justine, Chen Yu-Wei, McKay Rana R

Abstract excerpt

PURPOSE: Circulating tumor DNA (ctDNA) next-generation sequencing complements tissue-based testing and offers insights into prognosis, treatment selection, and tumor evolution. Despite advances in metastatic castration-resistant prostate cancer (mCRPC) therapies, resistance remains a challenge. This real-world study evaluates longitudinal ctDNA changes following systemic treatments. EXPERIMENTAL DESIGN: We...

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Topics

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Share to Circulating Tumor DNA
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasm Metastasis

Share to Poly(ADP-ribose) Polymerase Inhibitors

Share to Prostatic Neoplasms, Castration-Resistant

Share to Receptors, Androgen

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Source

Identifiers

PMID: 41746190
DOI: 10.1158/1078-0432.CCR-25-3071

Genes

AR
ATM
BRCA1
BRCA2
CDK12
EGFR
PIK3CA
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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