Article

Molecular dynamics analysis of Superoxide Dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression

2022-12-05

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the superoxide dismutase 1 ( SOD1 ) gene are the second most common known cause of ALS. SOD1 variants express high phenotypic variability and over 200 have been reported in people with ALS. Investigating how different SOD1 variants affect the protein dynamics might help in understanding their pathogenic mechanism and explaining their heterogeneous clinical presentation. It was pr...

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Literature Corpus work: bab53d2d-0de8-5364-8f15-2e7568d1dc88
DOI: 10.1101/2022.12.05.519128

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