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Molecular dynamics analysis of superoxide dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression

1 Jan 2023

Abstract excerpt

Mutations in the superoxide dismutase 1 ( SOD1 ) gene are the second most common known cause of ALS. SOD1 variants express high phenotypic variability and over 200 have been reported in people with ALS. It was previously proposed that variants can be broadly classified in two groups, ‘wild-type like' (WTL) and ‘metal binding region' (MBR) variants, based on their structural location and biophysical properties....

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PMID: 37954145
DOI: 10.1016/j.csbj.2023.09.016

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