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Article

Functional Interaction between Apolipophorins and Complement Regulate the Mosquito Immune Response to Systemic Infections

1 Jan 2016

Abstract excerpt

The complement-like protein thioester-containing protein 1 (TEP1) is the hallmark effector molecule against Plasmodium ookinetes in the malaria vector Anopheles gambiae. We have previously shown that the knockdown of the noncatalytic clip domain serine protease CLIPA2 increased TEP1-mediated killing rendering mosquitoes more resistant to Plasmodium, bacterial and fungal infections. Here, CLIPA2...

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PMID: 26950600
DOI: 10.1159/000443883

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