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Article

Structural basis for conserved complement factor-like function in the antimalarial protein TEP1

2 Jul 2007

Abstract excerpt

Thioester-containing proteins (TEPs) are a major component of the innate immune response of insects to invasion by bacteria and protozoa. TEPs form a distinct clade of a superfamily that includes the pan-protease inhibitors alpha(2)-macroglobulins and vertebrate complement factors. The essential feature of these proteins is a sequestered thioester bond that, after cleavage in a protease-sensitive region of the...

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PMID: 17606907
DOI: 10.1073/pnas.0704967104

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Structural basis for conserved complement factor-like function in the antimalarial protein TEP1PMID 17606907Read ↗

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