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Article

Diverged alleles of the Anopheles gambiae leucine-rich repeat gene APL1A display distinct protective profiles against Plasmodium falciparum.

PloS one - 1 Jan 2012

Holm Inge, Lavazec Catherine, Garnier Thierry, Mitri Christian, Riehle Michelle M, Bischoff Emmanuel, Brito-Fravallo Emma, Takashima Eizo, Thiery Isabelle, Zettor Agnes, Petres Stephane, Bourgouin Catherine, Vernick Kenneth D, Eiglmeier Karin

Abstract excerpt

Functional studies have demonstrated a role for the Anopheles gambiae APL1A gene in resistance against the human malaria parasite, Plasmodium falciparum. Here, we exhaustively characterize the structure of the APL1 locus and show that three structurally different APL1A alleles segregate in the Ngousso colony. Genetic association combined with RNAi-mediated gene silencing revealed that APL1A alleles display...

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PMID: 23285147
DOI: 10.1371/journal.pone.0052684
PMCID: PMC3532451

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